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Title:

Deactivation rate of camptothecin determined by factor analysis of steady-state fluorescence and absorption spectra

Group publication title:

Optica Applicata

Creator:

Ziomkowska, Blanka ; Kruszewski, Stefan ; Siuda, Ryszard ; Cyrankiewicz, Michał

Contributor:

Gaj, Miron. Redakcja ; Wilk, Ireneusz. Redakcja

Subject and Keywords:

optyka ; camptothecin ; fluorescence ; absorption ; factor analysis

Description:

Optica Applicata, Vol. 36, 2006, nr 1, s. 137-146

Abstrakt:

Camptothecin is a fluorescent compound exhibiting strong anticancer properties. A serious limitation to clinical application of this compound is its hydrolysis, when biologically active lactone form converts into inactive carboxylate. There are some differences in the shapes of both fluorescence and absorption spectra of the lactone and carboxylate forms of camptothecin. Therefore, during hydrolysis resultant fluorescence and absorption spectra evolve. Factor analysis of fluorescence/absorption spectra recorded during the hydrolysis process of camptothecin enables one to determine the temporary concentration of the lactone and carboxylate forms and obtain the deactivation rate of this compound.

Publisher:

Oficyna Wydawnicza Politechniki Wrocławskiej

Place of publication:

Wrocław

Date:

2006

Resource Type:

artykuł

Source:

<sygn. PWr A3481II> ; click here to follow the link ; click here to follow the link

Language:

eng

Relation:

Optica Applicata ; Optica Applicata, Vol. 36, 2006 ; Optica Applicata, Vol. 36, 2006, nr 1 ; Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki

Rights:

Wszystkie prawa zastrzeżone (Copyright)

Access Rights:

Dla wszystkich w zakresie dozwolonego użytku

Location:

Politechnika Wrocławska