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Title:

Affinity of new anticancer agent, DB-174, to membranes and HSA determined by fluorescence spectroscopy methods

Group publication title:

Optica Applicata

Creator:

Kruszewski, Stefan ; Bom, David ; Ziomkowska, Blanka ; Cyrankiewicz, Michał

Contributor:

Gaj, Miron. Redakcja ; Wilk, Ireneusz. Redakcja

Subject and Keywords:

optyka ; camptothecin ; fluorescence anisotropy ; membranes ; human serum albumin (HSA)

Description:

Optica Applicata, Vol. 36, 2006, nr 2-3, s. 199-207

Abstrakt:

The application of fluorescence spectroscopy methods to determining the properties of camptothecins – promising anticancer agents – are described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecin and its analogues to cell membranes and human serum albumin (HSA) that is important for potential clinical applications of these agents, and permits the selection from many camptothecin analogues those ones exhibiting desirable biomedical properties. Binding properties of 7-trimethylsilyl-ethyl-10 hydroxy-camptothecin are the subject of this paper.

Publisher:

Oficyna Wydawnicza Politechniki Wrocławskiej

Place of publication:

Wrocław

Date:

2006

Resource Type:

artykuł

Source:

<sygn. PWr A3481II> ; click here to follow the link ; click here to follow the link

Language:

eng

Relation:

Optica Applicata ; Optica Applicata, Vol. 36, 2006 ; Optica Applicata, Vol. 36, 2006, nr 2-3 ; Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki

Rights:

Wszystkie prawa zastrzeżone (Copyright)

Access Rights:

Dla wszystkich w zakresie dozwolonego użytku

Location:

Politechnika Wrocławska